I have a particular soft spot for your question because I've been there myself. In 2001, I had a very handicapped child and had to stop working to take care of him. Then I had another child a year later. I thought that was the end of my career! But you know what? I'm happier and more fulfilled in my professional life now than I ever have been. It can happen.
First, I knew I had to work from home so I could actually work. I hooked up with a former employer who knew I was trustworthy and needed some resourcing done for his new business. It suited him because his overhead costs were next to nothing - just a long-distance phone bill and my time.
I was so enthusiastic to be back on the scene that I made a lot of connections and had a lot of success. One thing blossomed into another and soon I was growing his business at an appreciable rate. I was recruiting all over Europe from my living room! My kids were getting more independent too.
There came a point of departure with my ex-boss when he moved in a different direction. I was so used to working from home and having an active on-line social life that I couldn't imagine going into someone else's office and producing the same results. So, when we moved to yet another country, I set up my own company. I know there's a recession out there, but I haven't looked back since.
I really believe if you do good work, make good connections and have the right attitude (you clearly do), you can succeed from a home-based office. The trick is managing your family time, but that's another story. ;-)
I hope that helps a little. Free free to contact me if you want to discuss things further.