Toni Bowers writes a nice one here about three questions that should be asked during an interview...

1. What can you tell me about the people I’ll be working with?

2. How do you approach problem solving?

3. What do you see as the ultimate goal of your department or team?

I'm not set on the second question; the first should distinguish between professional and personal and the second really needs to focus on both long and short. All in all though, these far surpass the ubiquitous benefits questions.

What I like to ask the recruiter, hiring manager, cohorts, etc. is for them to describe for me the job that would get them to say Yes to the question, if I were to present to you an opportunity that was superior in every way to your present role would you be interested in talking to me about it?

Every professional has their price...